PROSTATE CRYOABLATION
CLINICAL DATA

a. Primary Prostate Cryoablation

The effectiveness of cancer therapies is measured in terms of the number of years patients enjoy being diseasefree after treatment. The graph below shows the percentage of patients who are cancer free a number of years after treatment. It demonstrates that cryoablation is at least as effective as any other therapy – including surgery – at giving patients a life free from cancer.

Biochemical Disease-Free Survival (% Patients) after Treatment for Primary Prostate Cancer
A high number means more people were disease-free at time of follow up*

Since prostate cancer treatments have similar survival rates, side effects and quality of life are important considerations when choosing your treatment.

Change in Urinary Symptoms (% Return to Quality-of-Life Baseline) in Prostate Cancer Patients

Source: Malcolm et al. J Urol (2010)

Change in Urinary Incontinence (% Return to Quality-of-Life Baseline) in Prostate Cancer Patients

Source: Malcolm et al. J Urol (2010)

Primary prostate cryoablation offers many advantages over other treatment options, including:

  • A minimally invasive (no incisions), curative treatment.
  • 15-year clinical data supports safety and effectiveness in treating prostate cancer.
  • Single treatment, performed on outpatient basis or requiring just one overnight stay.
  • Short hospital stay reduces risk of hospital-acquired infection.
  • Short recovery time permits rapid return to everyday life.
  • Lower risk of incontinence (leaking urine) than with any other therapy.
  • May improve urinary function in patients experiencing problems prior to cryoablation.
  • Minimal or no pain.
  • No need for radiation or radioactive substances and risk of associated side effects (e.g. secondary cancer).
  • Low risk of rectal damage or irritation.
  • Can be used when other treatments, such as intensity modulated radiation therapy (IMRT), external beam radiotherapy (EBRT) and brachytherapy have failed to cure prostate cancer.

Why did I choose prostate cryotherapy?

b. Salvage Prostate Cryoablation

Cryotherapy performed on patients who have recurrent prostate cancer, having failed radiation therapy or some other type of primary treatment, is referred to as salvage prostate cryoablation. Unlike hormonal therapy, salvage prostate cryoablation is a curative treatment for prostate cancer recurrence.

Most patients who failed radiation are put on hormonal therapy. Hormonal therapy cannot cure prostate cancer – it can only delay the progress of the cancer. Hormonal therapy also has many unpleasant side effects. Recently, the US Food and Drug Administration has warned about a link between heart disease and diabetes in prostate cancer patients treated with hormones.

Other salvage treatment options include salvage prostatectomy (surgical removal of the prostate) or additional radiation therapy.

How did Dr. Waterhouse help you in making the final treatment decision

Salvage prostate cryoablation offers many advantages over other salvage treatment options, including:

  • Curative therapy.
  • Single-treatment session.
  • Compared to surgery and radiation, low rates of incontinence (leaking urine).
  • Minimally invasive (no incisions).
  • No radiation or hormones.
  • None of the side effects associated with hormones.
  • Short hospital stay and quick recovery.
  • Can be repeated, if necessary.

5-Year Biochemical Disease-Free Survival (%) After Prostate Cancer Salvage Therapy

A high number means more people were disease-free at time of follow up

Source:  Published results for prostate cancer salvage patients:
Salvage Prostatectomy:   Paparel et al. (2010)                  HIFU: Chalasani et al. (2010)
                                        Boukaram et al. (2010)              Cryotherapy: Boukaram et al. (2010)
Brachytherapy:                 Boukaram et al. (2010)                   

 

Risk of Incontinence (%) After Prostate Cancer Salvage Therapy

A low risk means less likelihood of incontinence

Source: Published results for prostate cancer salvage patients:
Salvage Prostatectomy:  Boukaram et al. (2010)                                     HIFU: Boukaram et al. (2009)
Brachytherapy:               Boukaram et al. (2010)                                     Cryotherapy: Langenhuijsen et al. (2009)

c. Focal Prostate Cryoablation



1. Bahn et al. Endourology (2006)                     a: Stable PSA (ASTRO Definition
2. Lambert et al. Urology (2007)                       b: Stable PSA (Nadir+1)
3. Onik et al. Urol Oncol (2008)                         c: Stable PSA (Phoenix Definition)
4. Truesdale et al. Cancer Journal (2010)