LUNG CRYOABLATION
INDICATION OVERVIEW

Cryoablation for treating tumors that have spread to the lungs (tumor metastasis) is being recognized by more and more physicians around the world as a potentially effective way to treat these tumors. This procedure is typically performed by an Interventional Radiologist. BTG is the world leader in providing cryoablation solutions for lung metastases ablation.

Although surgical resection is the treatment of choice for stage I non-small cell lung cancer, only one third of patients are suitable candidates1. For patients with inoperable tumors, stereotactic body radiation is often employed, but several series suggest that percutaneous cryoablation has efficacy comparable to less aggressive surgical therapies in primary tumors2,3 as well as acceptable control3,4 of secondary lesions. Cryoablation also has limited procedural morbidity relative to other ablative techniques, particularly in the treatment of large and mediastinal tumors4,5,7.

Lung cryoablation is a safe and effective minimally invasive therapy:

  • Proven efficacy in primary and metastatic tumours1-5
  • Excellent safety profile1-8
  • Real-time control of iceball with images that correlate to pathologic ablation zone1-10
  • Can be performed under conscious sedation
    • Minimal pain associated with the procedure1-4,6-8
    • Allows for breath-holding if desirable4,8
  • Suitable for lesions in locations close to critical structures that may preclude other ablative technologies:3,6,8
    • Mediastinum
    • Pericardium
    • Diaphragm
    • Pleura

References
 1. Pusceddu C et al. Eur J Radiol 2013; 82:e246-53.
 2. Inoue M et al. Biomed Res Int 2014; Article ID 521691.
 3. de Baere T et al. J Thorac Oncol 2015; 10:1468-74.
 4. Zhang X et al. Eur J Radiol 2012; 81:3354-62.
 5. Moore W et al. J Vasc Interv Radiol 2015; 26:312-19.
 6. Colak E et al. Diagn Interv Radiol 2014; 20:316-22.
 7. Wang H et al. Radiology 2005; 235:289-98.
 8. Yilmaz S et al. Insights Imaging 2016; 7:223-32.
 9. Kawamura M et al. J Thorac Cardiovasc Surg 2006; 131(5): 1007-13.
10. Zemylak A et al. J Am Coll Surg 2010; 211:68-72.
11. Yamauchi Y et al. PLoS ONE 2011; 6(11). Article ID e27086.
12. Inoue M et al. J Vasc Interv Radiol 2012; 23:295-302.
13. Yamauchi Y et al. PLoS ONE 2012; 7:e33223