How is Bead Block® packaged?

  • Bead Block® is presented in a 20ml syringe
  • Each syringe is presented in a sterile, sealed pre-formed Tyvek® peel-away tray with a label coloured to denote the specific size range
  • Each syringe contains approximately 2ml of Bead Block® in non-pyrogenic,  sterile, physiological buffered saline
  • Each syringe is intended for single patient use only
  • The syringe should not be re-sterilised and any unused material should be discarded

What size range of Bead Block® is available?

  • Bead Block is available in five sizes from 100µm to 1200µm
Bead Block® sizes
Label Colour Nominal Bead size Volume of beads
Yellow 100-300µm 2ml
Blue 300-500µm 2ml
Red 500-700µm 2ml
Green 700-900µm 2ml
Purple 900-1200µm 2ml

What are the indications for Bead Block®?

Bead Block® is a 510K cleared embolic agent intended for the purpose of embolizing the blood vessels of a variety of hypervascularized tumours including uterine fibroids and arteriovenous malformations. 

How many beads are there per syringe of Bead Block®?

  • When using Bead Block®, the volume of embolic required to reach the desired end point is the critical factor
  • The number of individual beads is not usually considered when deciding the volume to deliver to the patient 


Bead Block® Bead Block®
Bead Block®
Bead Block®
Bead Block®
Bead Block®
Approximate number
of beads in 2ml
Bead Block® syringe*
200,000 40,000 10,000 4,000 2,500

Theoretical calculation based on the average diameters of a normal distribution of beads in a vial. Biocompatibles data on file

What is Bead Block® tinted with?

Bead Block® is tinted with a dye called Reactive Blue 4 (CI 61205). This dye has many names such as:
  • Procion Blue MR
  • Reactive Brilliant Blue
  • Reactive Blue MR
Reactive Blue 4 (CI 61205) has been used in many applications and is routinely used for the tinting of contact lenses

What is the preparation and administration protocol for Bead Block®?

  1. Draw up contrast medium directly into the Bead Block® pre-filled syringe. To Bead Block® sinks, add more contrasts. If Bead Block® floats, add more saline.
  2. Remove all air from syringe.
  3. Gently invert the 20ml syringe several times to evenly suspend the Bead Block® contrast solution
  4. Do not use a shaking motion.
  5. Wait to allow Bead Block® to suspend properly.

Procedure Prep 1Procedure Prep 2

What type of contrast should I add to Bead Block®? How much should I use?

  • Always use a non-ionic contrast medium
  • The quality of contrast medium depends on its concentration and also the size of Bead Block® being used

What catheter sizes can I use with Bead Block®?

  • Bead Block® is compatible with all 4F and 5F catheters (minimum ID of 0.040”/1040µm)

How long will Bead Block® stay in the arteries?

  • Bead Block® and LC Bead® are made from identical materials and are both classified as permanent embolic agents

No visible change to the LC Bead® product has been observed in histological analyses reported in:3 month intrahepatic implants in vivo*

  • 6 month subcutaneous implants in vivo**
  • 12 month intracerebral implants in vivo***
  • Therefore, Bead Block® is expected to perform in a similar manner to LC Bead®.
 * Lewis AL, et al, JVIR (2006): 17; 1335-1343
** NAmSA, report on file at Biocompatibles
*** Vinchon-Petit S, et al, Int J Pharmaceut (2010): 402: 184-9

What is the recommended protocol for Bead Block® in UFE?

Patient Selection:

  • Women with symptomatic fibroids who have not responded to hormonal treatment


  • Pregnant women
  • Active or suspected pelvic inflammatory disease
  • Malignancy of the pelvic region
  • Endometrial neoplasia or hyperplasia
  • Presence of submucosal fibroids with greater than 50% growth into the uterine cavity
  • Presence of pedunculated serosal fibroid as the dominant fibroid(s)
  • Fibroids with significant collateral feeding by vessels other than the uterine arteries